Can biotechnology lead the way toward a sustainable pharmaceutical industry?

The impact-intensive and rapidly growing pharmaceutical industry must ensure its sustainability. This study reveals that environmental sustainability assessments have been conducted for only around 0.2% of pharmaceuticals, environmental impacts have significant variations among the assessed products, and different impact categories have not been consistently studied. Highly varied impacts require assessing more products to understand the industry's sustainability status. Reporting all impact categories will be crucial, especially when comparing production technologies. Biological production of (semi)synthetic pharmaceuticals could reduce their environmental costs, though the high impacts of biologically produced monoclonal antibodies should also be optimized. Considering the sustainability potential of biopharmaceuticals from economic, environmental, and social perspectives, collaboratively guiding their immense market growth would lead to the industry's sustainability transition.

ß-Zeolite-Assisted Lignin-First Fractionation in a Flow-Through Reactor*.

In the present work, a hydrogen-free one-step catalytic fractionation of woody biomass using commercial ß-zeolite as catalyst in a flow-through reactor was carried out. Birch, spruce, and walnut shells were compared as lignocellulosic feedstocks. ß-Zeolite acted as a bifunctional catalyst, preventing lignin repolymerization due to its size-selective properties and also cleaving ß-O-4 lignin intralinkages while stabilizing reactive intermediates. A rate-limiting step analysis using different reactor configurations revealed a mixed regime where the rates of both solvolytic delignification and zeolite-catalyzed depolymerization and dehydration affected the net rate of aromatic monomer production. Oxalic acid co-feeding was found to enhance monomer production at moderate concentrations by improving solvolysis, while it caused structural changes to the zeolite and led to lower monomer yields at higher concentrations. Zeolite stability was assessed through catalyst recycling and characterization. Main catalyst deactivation mechanisms were found to be coking and leaching, leading to widening of the pores and decrease of zeolite acidity, respectively.